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KMID : 0618720130190020001
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Journal of The Korea Institute of Oriental Medicine Informatics
2013 Volume.19 No. 2 p.1 ~ p.20
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The Effects of Red Ginseng and Fermented Red Ginseng on Neurotoxicity in Mice Induced by MPTP
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Yoo Hyun-Sook
Na Sam-Sik
Chong Myong-Soo
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Abstract
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This research observed the interrelations between the active components found specifically in red ginseng and fermented red ginseng from among the variety of ginseng variations and the protective effect and anti-oxidant effect exercised on brain cells in the animal model for MPTP-induced neurotoxic Parkinson's Disease and obtained the following conclusions. The results above comprehensively demonstrated that the fermented red ginseng extract exercised greater protective effects against oxidant brain damage by MPTP when compared to the group administered with the red ginseng extract. This was induced an increase in TH protein expression, and further raised the efficiency of the anti-oxidant enzyme defensive system against neurotoxicity, thereby restraining the lipid peroxidation caused by the active oxygen generated during the course of MPTP metabolism and enhancing the body's defensive capacities in response to tissue damage, thereby demonstrating a protective effect against MPTP induced neurotoxicity.
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KEYWORD
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Red Ginseng , Fermented Red Ginseng , Neurotoxicity , MPTP
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